Reverse Transcriptase
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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Reverse Transcriptase Related Products (269)
Related Products (269)
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EFdA-TP
0 ImagesCat. No.: HY-138561CAS No.: 950913-56-1EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms.
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BILR 355
0 ImagesCat. No.: HY-118632CAS No.: 380378-81-4BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase (RT). BILR 355 can be used for HIV infections research.
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Artoheteronin
0 ImagesCat. No.: HY-N17392CAS No.: 2771017-28-6Artoheteronin is a prenylated coumarin found in the fruits of Artocarpus heterophyllus. Artoheteronin can inhibit HIV-1 reverse transcriptase activity with an EC50 of 0.18 μM. Artoheteronin shows anti-inflammatory activity and inhibits nitric oxide production. Artoheteronin can be used for the researches of HIV infection and inflammatory disease.
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Amdoxovir
0 ImagesCat. No.: HY-106155CAS No.: 145514-04-1Synonyms: DAPDAmdoxovir (DAPD) is an orally active nucleoside reverse transcriptase inhibitor. Amdoxovir is active against wild-type and NRTl-resistant viruses. Amdoxovir is the prodrug of dioxolane guanosine. Amdoxovir can be used for research of HIV/AIDS.
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Didanosine-13C2,15N
0 ImagesCat. No.: HY-W765997Synonyms: 2',3'-Dideoxyinosine-13C2,15N; ddI-13C2,15NDidanosine-13C2,15N (2',3'-Dideoxyinosine-13C2,15N; ddI-13C2,15N) is the 13C- and 15N-labeled labeled Didanosine (HY-B0249). Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV.
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Lamivudine-15N,d2
0 ImagesCat. No.: HY-B0250SSynonyms: BCH-189-15N,d2Lamivudine-15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
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Stavudine-d4
0 ImagesCat. No.: HY-B0116SCAS No.: 1219803-67-4Stavudine-d4 is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
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HIV-1-IN-83
0 ImagesCat. No.: HY-175351HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM.
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GSK5750
0 ImagesCat. No.: HY-116454CAS No.: 1312345-89-3GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism.
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DC20
0 ImagesCat. No.: HY-176169CAS No.: 2892399-89-0DC20 is an orally active non-nucleoside reverse transcriptase inhibitor with an EC50 of 0.004 μM aganist HIV-1IIIB.
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Trovirdine hydrochloride
0 ImagesCat. No.: HY-15350CAS No.: 148311-89-1Synonyms: LY 300046 hydrochlorideTrovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells.
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Dapivirine-d4
0 ImagesCat. No.: HY-14266S1CAS No.: 1309283-15-5Synonyms: TMC120-d4; R147681-d4Dapivirine-d4 (TMC120-d4) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
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HIV-1 inhibitor-53
0 ImagesCat. No.: HY-152200CAS No.: 2883496-10-2HIV-1 inhibitor-53 is a dual HIV-1 protease and reverse transcriptase inhibitor. HIV-1 inhibitor-53 inhibits HIV-1 protease (PR) and reverse transcriptase (RT) activity with IC50 values of 1.93 nM and 2.35 μM, respectively. HIV-1 inhibitor-53 can be used for the research of acquired immune deficiency syndrome (AIDS).
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Tenofovir alafenamide-d5 fumarate
0 ImagesCat. No.: HY-W653961Synonyms: GS-7340-d5 fumarateTenofovir alafenamide-d5 fumarate (GS-7340-d5 fumarate) is the deuterium labeled Tenofovir alafenamide fumarate (HY-15232A). Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
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HIV-1 inhibitor-41
0 ImagesCat. No.: HY-147841CAS No.: 3033425-97-4
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RDEA 806
0 ImagesCat. No.: HY-105249CAS No.: 878670-61-2RDEA 806 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type HIV-1 (EC50 = 3.05 nM) and NNRTI-resistant HIV-1.
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Tenofovir (Standard)
0 ImagesSynonyms: GS 1278 (Standard); PMPA (Standard)
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Melanochromone
0 ImagesCat. No.: HY-N17741CAS No.: 350229-67-3Melanochromone is an HIV-1 reverse transcriptase inhibitor that exhibits anti-HIV-1 activity. Melanochromone can be used in research related to HIV-1 infection.
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Nigranoic acid
0 ImagesCat. No.: HY-122935CAS No.: 39111-07-4Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
